Frederick Carl Frieseke was born in Owosso, Michigan. After studying for a short while at the Art Institute of Chicago and the Art Students League in New York, Frieseke left for France in 1898, and almost all of his career was spent as an expatriate, with ties to the United States maintained through his New York dealer, William MacBeth, and by occasional visits to America.
Following the pattern of innumerable young Americans, he enrolled at the Academie Julian where he studied with Benjamin Constant (1845-1902) and Jean-Paul Laurens (1838-1921).
He appears to have had at least brief contact with and to have been influenced by James McNeill Whistler, who had recently opened his Academie Carmen in Paris.
He married Eva Graham and in 1871 their daughter Edith was born. Their son, Frederick Carl, was born in Owosso in 1874.