The Calumny of Apelles is a tempera painting by Italian Renaissance painter Sandro Botticelli. Based on the description of a painting by Apelles, the work was completed in approximately 1494. It is on display in the Uffizi in Florence.
In The Calumny of Apelles, Botticelli drew on the description of a painting by Apelles, a Greek painter of the Hellenistic Period.