A painter of religious compositions and portraits, Benson was active in the Low Countries but was of Italian origin.
The first information on the artist dates from 1518 when he became a citizen of Bruges.
The following year he was registered as an independent master in the painters and decorators’ guild in hat city, whose records state that he was originally from Lombardy. Benson first worked as an assistant in the workshop of Gerard David who exercised an important influence over his style and against whom he initiated a court case.